Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance

Plasmodium falciparum parasites resistant to antimalarial treatments have hindered malaria disease control. Sulfadoxine-pyrimethamine (SP) was used globally as a first-line treatment for malaria after wide-spread resistance to chloroquine emerged and, although replaced by artemisinin combinations, i...

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發表在:PLoS Genet
Main Authors: Turkiewicz, Anna, Manko, Emilia, Sutherland, Colin J., Diez Benavente, Ernest, Campino, Susana, Clark, Taane G.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774857/
https://ncbi.nlm.nih.gov/pubmed/33382691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009268
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