Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana

Sulfadoxine-pyrimethamine (SP) is used as malaria chemoprophylaxis for pregnant women and children in Ghana. Plasmodium falciparum resistance to SP is linked to mutations in the dihydropteroate synthase gene (pfdhps), dihydrofolate reductase gene (pfdhfr) and amplification of GTP cyclohydrolase 1 (p...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Osei, Musah, Ansah, Felix, Matrevi, Sena A., Asante, Kwaku P., Awandare, Gordon A., Quashie, Neils B., Duah, Nancy O.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162080/
https://ncbi.nlm.nih.gov/pubmed/30265714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204871
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