SCF(β-TRCP) E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation

Wnt signaling has emerged as a major regulator of tissue development by governing the self-renewal and maintenance of stem cells in most tissue types. As a key upstream regulator of the Wnt pathway, the transmembrane E3 ligase ZNRF3 has recently been established to play a role in negative regulation...

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Veröffentlicht in:Protein Cell
Hauptverfasser: Ci, Yanpeng, Li, Xiaoning, Chen, Maorong, Zhong, Jiateng, North, Brian J., Inuzuka, Hiroyuki, He, Xi, Li, Yu, Guo, Jianping, Dai, Xiangpeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Higher Education Press 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160385/
https://ncbi.nlm.nih.gov/pubmed/29497989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-018-0510-2
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