Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

BACKGROUND: No pharmacological therapy exists for calcific aortic valve disease (CAVD), which confers a dismal prognosis without invasive valve replacement. The search for therapeutics and early diagnostics is challenging since CAVD presents in multiple pathological stages. Moreover, it occurs in th...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Circulation
Autori principali: Schlotter, Florian, Halu, Arda, Goto, Shinji, Blaser, Mark C., Body, Simon C., Lee, Lang H., Higashi, Hideyuki, DeLaughter, Daniel M., Hutcheson, Joshua D., Vyas, Payal, Pham, Tan, Rogers, Maximillian A., Sharma, Amitabh, Seidman, Christine E., Loscalzo, Joseph, Seidman, Jonathan G., Aikawa, Masanori, Singh, Sasha A., Aikawa, Elena
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160370/
https://ncbi.nlm.nih.gov/pubmed/29588317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.032291
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