Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

BACKGROUND: No pharmacological therapy exists for calcific aortic valve disease (CAVD), which confers a dismal prognosis without invasive valve replacement. The search for therapeutics and early diagnostics is challenging since CAVD presents in multiple pathological stages. Moreover, it occurs in th...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Schlotter, Florian, Halu, Arda, Goto, Shinji, Blaser, Mark C., Body, Simon C., Lee, Lang H., Higashi, Hideyuki, DeLaughter, Daniel M., Hutcheson, Joshua D., Vyas, Payal, Pham, Tan, Rogers, Maximillian A., Sharma, Amitabh, Seidman, Christine E., Loscalzo, Joseph, Seidman, Jonathan G., Aikawa, Masanori, Singh, Sasha A., Aikawa, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160370/
https://ncbi.nlm.nih.gov/pubmed/29588317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.032291
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