Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

BACKGROUND: No pharmacological therapy exists for calcific aortic valve disease (CAVD), which confers a dismal prognosis without invasive valve replacement. The search for therapeutics and early diagnostics is challenging since CAVD presents in multiple pathological stages. Moreover, it occurs in th...

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Опубликовано в: :Circulation
Главные авторы: Schlotter, Florian, Halu, Arda, Goto, Shinji, Blaser, Mark C., Body, Simon C., Lee, Lang H., Higashi, Hideyuki, DeLaughter, Daniel M., Hutcheson, Joshua D., Vyas, Payal, Pham, Tan, Rogers, Maximillian A., Sharma, Amitabh, Seidman, Christine E., Loscalzo, Joseph, Seidman, Jonathan G., Aikawa, Masanori, Singh, Sasha A., Aikawa, Elena
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160370/
https://ncbi.nlm.nih.gov/pubmed/29588317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.032291
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