Analysis of Pedigree Data in Populations with Multiple Ancestries: Strategies for Dealing with Admixture in Caribbean Hispanic Families from the ADSP

Multipoint linkage analysis is an important approach for localizing disease-associated loci in pedigrees. Linkage analysis, however, is sensitive to misspecification of marker allele frequencies. Pedigrees from recently-admixed populations are particularly susceptible to this problem because of the...

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Detalhes bibliográficos
Publicado no:Genet Epidemiol
Main Authors: Nafikov, Rafael A., Nato, Alejandro Q., Sohi, Harkirat, Wang, Bowen, Brown, Lisa, Horimoto, Andrea R., Vardarajan, Badri N., Barral, Sandra M., Tosto, Giuseppe, Mayeux, Richard P., Thornton, Timothy A., Blue, Elizabeth, Wijsman, Ellen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160322/
https://ncbi.nlm.nih.gov/pubmed/29862559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22133
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