Estimating and adjusting for ancestry admixture in statistical methods for relatedness inference, heritability estimation, and association testing

It is well known that genetic association studies are not robust to population stratification. Two widely used approaches for the detection and correction of population structure are principal component analysis and model-based estimation of ancestry. These methods have been shown to give reliable i...

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Bibliografiske detaljer
Main Authors: Thornton, Timothy, Conomos, Matthew P, Sverdlov, Serge, Blue, Elizabeth M, Cheung, Charles YK, Glazner, Christopher G, Lewis, Steven M, Wijsman, Ellen M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Proceedings
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143704/
https://ncbi.nlm.nih.gov/pubmed/25519330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-8-S1-S5
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