Identity-by-descent graphs offer a flexible framework for imputation and both linkage and association analyses

We demonstrate the flexibility of identity-by-descent (IBD) graphs for genotype imputation and testing relationships between genotype and phenotype. We analyzed chromosome 3 and the first replicate of simulated diastolic blood pressure. IBD graphs were obtained from complete pedigrees and full multi...

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Detalhes bibliográficos
Main Authors: Blue, Elizabeth Marchani, Cheung, Charles YK, Glazner, Christopher G, Conomos, Matthew P, Lewis, Steven M, Sverdlov, Serge, Thornton, Timothy, Wijsman, Ellen M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Proceedings
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143703/
https://ncbi.nlm.nih.gov/pubmed/25519371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-8-S1-S19
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