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Paired D10A Cas9 nickases are sometimes more efficient than individual nucleases for gene disruption
The use of paired Cas9 nickases instead of Cas9 nuclease drastically reduces off-target effects. Because both nickases must function for a nickase pair to make a double-strand break, the efficiency of paired nickases can intuitively be expected to be lower than that of either corresponding nuclease...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6158698/ https://ncbi.nlm.nih.gov/pubmed/29584876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky222 |
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