Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis

Viral RNA-dependent RNA polymerases (RdRps) are major determinants of high mutation rates and generation of mutant spectra that mediate RNA virus adaptability. The RdRp of the picornavirus foot-and-mouth disease virus (FMDV), termed 3D, is a multifunctional protein that includes a nuclear localizati...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: de la Higuera, Ignacio, Ferrer-Orta, Cristina, Moreno, Elena, de Ávila, Ana Isabel, Soria, María Eugenia, Singh, Kamalendra, Caridi, Flavia, Sobrino, Francisco, Sarafianos, Stefan G., Perales, Celia, Verdaguer, Nuria, Domingo, Esteban
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158410/
https://ncbi.nlm.nih.gov/pubmed/30068642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01119-18
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