Rare haplotype load as marker for lethal mutagenesis

RNA viruses replicate with a template-copying fidelity, which lies close to an extinction threshold. Increases of mutation rate by nucleotide analogues can drive viruses towards extinction. This transition is the basis of an antiviral strategy termed lethal mutagenesis. We have introduced a new dive...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Gregori, Josep, Soria, María Eugenia, Gallego, Isabel, Guerrero-Murillo, Mercedes, Esteban, Juan Ignacio, Quer, Josep, Perales, Celia, Domingo, Esteban
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169937/
https://ncbi.nlm.nih.gov/pubmed/30281674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204877
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