Rare haplotype load as marker for lethal mutagenesis

RNA viruses replicate with a template-copying fidelity, which lies close to an extinction threshold. Increases of mutation rate by nucleotide analogues can drive viruses towards extinction. This transition is the basis of an antiviral strategy termed lethal mutagenesis. We have introduced a new dive...

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Publicat a:PLoS One
Autors principals: Gregori, Josep, Soria, María Eugenia, Gallego, Isabel, Guerrero-Murillo, Mercedes, Esteban, Juan Ignacio, Quer, Josep, Perales, Celia, Domingo, Esteban
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169937/
https://ncbi.nlm.nih.gov/pubmed/30281674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204877
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