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Rare haplotype load as marker for lethal mutagenesis
RNA viruses replicate with a template-copying fidelity, which lies close to an extinction threshold. Increases of mutation rate by nucleotide analogues can drive viruses towards extinction. This transition is the basis of an antiviral strategy termed lethal mutagenesis. We have introduced a new dive...
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| Foilsithe in: | PLoS One |
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| Main Authors: | , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Public Library of Science
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6169937/ https://ncbi.nlm.nih.gov/pubmed/30281674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204877 |
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