Rare haplotype load as marker for lethal mutagenesis

RNA viruses replicate with a template-copying fidelity, which lies close to an extinction threshold. Increases of mutation rate by nucleotide analogues can drive viruses towards extinction. This transition is the basis of an antiviral strategy termed lethal mutagenesis. We have introduced a new dive...

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Foilsithe in:PLoS One
Main Authors: Gregori, Josep, Soria, María Eugenia, Gallego, Isabel, Guerrero-Murillo, Mercedes, Esteban, Juan Ignacio, Quer, Josep, Perales, Celia, Domingo, Esteban
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2018
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169937/
https://ncbi.nlm.nih.gov/pubmed/30281674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204877
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