Rare haplotype load as marker for lethal mutagenesis

RNA viruses replicate with a template-copying fidelity, which lies close to an extinction threshold. Increases of mutation rate by nucleotide analogues can drive viruses towards extinction. This transition is the basis of an antiviral strategy termed lethal mutagenesis. We have introduced a new dive...

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Publicado en:PLoS One
Autores principales: Gregori, Josep, Soria, María Eugenia, Gallego, Isabel, Guerrero-Murillo, Mercedes, Esteban, Juan Ignacio, Quer, Josep, Perales, Celia, Domingo, Esteban
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169937/
https://ncbi.nlm.nih.gov/pubmed/30281674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204877
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