Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype

Cell culture-produced hepatitis C virus (HCV) has been subjected to up to 100 serial passages in human hepatoma cells in the absence or presence of different doses of alpha interferon (IFN-α). Virus survival, genetic changes, fitness levels, and phenotypic traits have been examined. While high initi...

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Autors principals: Perales, Celia, Beach, Nathan M., Gallego, Isabel, Soria, Maria Eugenia, Quer, Josep, Esteban, Juan Ignacio, Rice, Charles, Domingo, Esteban, Sheldon, Julie
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Genetic Diversity and Evolution
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700284/
https://ncbi.nlm.nih.gov/pubmed/23637397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02824-12
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