Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir

Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagen. Here we show that favipiravir (T-705) is a potent mutagenic agent for hepatitis C virus (HCV) during its replication in human hepatom...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: de Ávila, Ana I., Gallego, Isabel, Soria, Maria Eugenia, Gregori, Josep, Quer, Josep, Esteban, Juan Ignacio, Rice, Charles M., Domingo, Esteban, Perales, Celia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068784/
https://ncbi.nlm.nih.gov/pubmed/27755573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164691
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