Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition

The N-terminal region of the foot-and-mouth disease virus (FMDV) 3D polymerase contains the sequence MRKTKLAPT (residues 16 to 24) that acts as a nuclear localization signal. A previous study showed that substitutions K18E and K20E diminished the transport to the nucleus of 3D and 3CD and severely i...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ferrer-Orta, Cristina, de la Higuera, Ignacio, Caridi, Flavia, Sánchez-Aparicio, María Teresa, Moreno, Elena, Perales, Celia, Singh, Kamalendra, Sarafianos, Stefan G., Sobrino, Francisco, Domingo, Esteban, Verdaguer, Nuria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468482/
https://ncbi.nlm.nih.gov/pubmed/25903341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03283-14
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