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A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

Resistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic nucleoside analogue ribavirin (1-β-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide...

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Библиографические подробности
Главные авторы: Agudo, Rubén, Ferrer-Orta, Cristina, Arias, Armando, de la Higuera, Ignacio, Perales, Celia, Pérez-Luque, Rosa, Verdaguer, Nuria, Domingo, Esteban
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928812/
https://ncbi.nlm.nih.gov/pubmed/20865120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001072
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