A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

Resistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic nucleoside analogue ribavirin (1-β-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Agudo, Rubén, Ferrer-Orta, Cristina, Arias, Armando, de la Higuera, Ignacio, Perales, Celia, Pérez-Luque, Rosa, Verdaguer, Nuria, Domingo, Esteban
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2010
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928812/
https://ncbi.nlm.nih.gov/pubmed/20865120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001072
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