A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

Resistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic nucleoside analogue ribavirin (1-β-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide...

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Detalhes bibliográficos
Main Authors: Agudo, Rubén, Ferrer-Orta, Cristina, Arias, Armando, de la Higuera, Ignacio, Perales, Celia, Pérez-Luque, Rosa, Verdaguer, Nuria, Domingo, Esteban
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928812/
https://ncbi.nlm.nih.gov/pubmed/20865120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001072
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