A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

Resistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic nucleoside analogue ribavirin (1-β-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide...

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Main Authors: Agudo, Rubén, Ferrer-Orta, Cristina, Arias, Armando, de la Higuera, Ignacio, Perales, Celia, Pérez-Luque, Rosa, Verdaguer, Nuria, Domingo, Esteban
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928812/
https://ncbi.nlm.nih.gov/pubmed/20865120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001072
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