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Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism

We previously characterized a foot-and-mouth disease virus (FMDV) with three amino acid replacements in its polymerase (3D) that conferred resistance to the mutagenic nucleoside analogue ribavirin. Here we show that passage of this mutant in the presence of high ribavirin concentrations resulted in...

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Bibliografiske detaljer
Udgivet i:Virology
Main Authors: Agudo, Rubén, de la Higuera, Ignacio, Arias, Armando, Grande-Pérez, Ana, Domingo, Esteban
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111656/
https://ncbi.nlm.nih.gov/pubmed/27136067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.04.023
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