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Tracing a protein’s folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange
The conformations populated during protein folding have been studied for decades; yet, their evolutionary importance remains largely unexplored. Ancestral sequence reconstruction allows access to proteins across evolutionary time, and new methods such as pulsed-labeling hydrogen exchange coupled wit...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6158009/ https://ncbi.nlm.nih.gov/pubmed/30204082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38369 |
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