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Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry
The kinetic folding of ribonuclease H was studied by hydrogen exchange (HX) pulse labeling with analysis by an advanced fragment separation mass spectrometry technology. The results show that folding proceeds through distinct intermediates in a stepwise pathway that sequentially incorporates coopera...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651421/ https://ncbi.nlm.nih.gov/pubmed/23603271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305887110 |
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