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Protein Folding—How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry

Advanced hydrogen exchange (HX) methodology can now determine the structure of protein folding intermediates and their progression in folding pathways. Key developments over time include the HX pulse labeling method with nuclear magnetic resonance analysis, development of the fragment separation met...

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Detalhes bibliográficos
Publicado no:Annu Rev Biophys
Main Authors: Englander, S. Walter, Mayne, Leland, Kan, Zhong-Yuan, Hu, Wenbing
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588872/
https://ncbi.nlm.nih.gov/pubmed/27145881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-062215-011121
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