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Protein Folding—How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry

Advanced hydrogen exchange (HX) methodology can now determine the structure of protein folding intermediates and their progression in folding pathways. Key developments over time include the HX pulse labeling method with nuclear magnetic resonance analysis, development of the fragment separation met...

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Bibliografiske detaljer
Udgivet i:Annu Rev Biophys
Main Authors: Englander, S. Walter, Mayne, Leland, Kan, Zhong-Yuan, Hu, Wenbing
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588872/
https://ncbi.nlm.nih.gov/pubmed/27145881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-062215-011121
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