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Protein Folding—How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry

Advanced hydrogen exchange (HX) methodology can now determine the structure of protein folding intermediates and their progression in folding pathways. Key developments over time include the HX pulse labeling method with nuclear magnetic resonance analysis, development of the fragment separation met...

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Publicat a:Annu Rev Biophys
Autors principals: Englander, S. Walter, Mayne, Leland, Kan, Zhong-Yuan, Hu, Wenbing
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588872/
https://ncbi.nlm.nih.gov/pubmed/27145881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-062215-011121
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