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Protein Folding—How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry

Advanced hydrogen exchange (HX) methodology can now determine the structure of protein folding intermediates and their progression in folding pathways. Key developments over time include the HX pulse labeling method with nuclear magnetic resonance analysis, development of the fragment separation met...

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Dettagli Bibliografici
Pubblicato in:Annu Rev Biophys
Autori principali: Englander, S. Walter, Mayne, Leland, Kan, Zhong-Yuan, Hu, Wenbing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588872/
https://ncbi.nlm.nih.gov/pubmed/27145881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-062215-011121
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