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Protein Folding—How and Why: By Hydrogen Exchange, Fragment Separation, and Mass Spectrometry

Advanced hydrogen exchange (HX) methodology can now determine the structure of protein folding intermediates and their progression in folding pathways. Key developments over time include the HX pulse labeling method with nuclear magnetic resonance analysis, development of the fragment separation met...

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Detalles Bibliográficos
Publicado en:Annu Rev Biophys
Main Authors: Englander, S. Walter, Mayne, Leland, Kan, Zhong-Yuan, Hu, Wenbing
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588872/
https://ncbi.nlm.nih.gov/pubmed/27145881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-062215-011121
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