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Evolutionary trend toward kinetic stability in the folding trajectory of RNases H

Proper folding of proteins is critical to producing the biological machinery essential for cellular function. The rates and energetics of a protein’s folding process, which is described by its energy landscape, are encoded in the amino acid sequence. Over the course of evolution, this landscape must...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lim, Shion A., Hart, Kathryn M., Harms, Michael J., Marqusee, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135364/
https://ncbi.nlm.nih.gov/pubmed/27799545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611781113
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