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The burst-phase folding intermediate of ribonuclease H changes conformation over evolutionary history

The amino acid sequence encodes the energy landscape of a protein. Therefore, we expect evolutionary mutations to change features of the protein energy landscape, including the conformations adopted by a polypeptide as it folds to its native state. Ribonucleases H (RNase H) from E. coli and T. therm...

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Bibliographic Details
Published in:Biopolymers
Main Authors: Lim, Shion An, Marqusee, Susan
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047922/
https://ncbi.nlm.nih.gov/pubmed/29152711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.23086
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