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Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations

PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Hart, Matthew R., Anderson, Donovan J., Porter, Christopher C., Neff, Tobias, Levin, Michael, Horwitz, Marshall S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157899/
https://ncbi.nlm.nih.gov/pubmed/30216339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007642
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