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Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations
PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and...
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| Pubblicato in: | PLoS Genet |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6157899/ https://ncbi.nlm.nih.gov/pubmed/30216339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007642 |
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