Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations

PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Hart, Matthew R., Anderson, Donovan J., Porter, Christopher C., Neff, Tobias, Levin, Michael, Horwitz, Marshall S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157899/
https://ncbi.nlm.nih.gov/pubmed/30216339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007642
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