Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

OBJECTIVE: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at the individual islet level. This is due in part to...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Taddeo, Evan P., Stiles, Linsey, Sereda, Samuel, Ritou, Eleni, Wolf, Dane M., Abdullah, Muhamad, Swanson, Zachary, Wilhelm, Josh, Bellin, Melena, McDonald, Patrick, Caradonna, Kacey, Neilson, Andrew, Liesa, Marc, Shirihai, Orian S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157638/
https://ncbi.nlm.nih.gov/pubmed/30098928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.07.003
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