A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets

BACKGROUND: The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR) may be a valuable predictor of islet quality and long term nutrient responsiveness. To date, high-throughput and user-friendly a...

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Detalhes bibliográficos
Main Authors: Wikstrom, Jakob D., Sereda, Samuel B., Stiles, Linsey, Elorza, Alvaro, Allister, Emma M., Neilson, Andy, Ferrick, David A., Wheeler, Michael B., Shirihai, Orian S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351473/
https://ncbi.nlm.nih.gov/pubmed/22606219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033023
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