Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

OBJECTIVE: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at the individual islet level. This is due in part to...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Metab
Hauptverfasser: Taddeo, Evan P., Stiles, Linsey, Sereda, Samuel, Ritou, Eleni, Wolf, Dane M., Abdullah, Muhamad, Swanson, Zachary, Wilhelm, Josh, Bellin, Melena, McDonald, Patrick, Caradonna, Kacey, Neilson, Andrew, Liesa, Marc, Shirihai, Orian S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157638/
https://ncbi.nlm.nih.gov/pubmed/30098928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.07.003
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