Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels

Fasting hyperinsulinemia precedes the development of type 2 diabetes. However, it is unclear whether fasting insulin hypersecretion is a primary driver of insulin resistance or a consequence of the progressive increase in fasting glycemia induced by insulin resistance in the prediabetic state. Herei...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Taddeo, Evan P., Alsabeeh, Nour, Baghdasarian, Siyouneh, Wikstrom, Jakob D., Ritou, Eleni, Sereda, Samuel, Erion, Karel, Li, Jin, Stiles, Linsey, Abdulla, Muhamad, Swanson, Zachary, Wilhelm, Joshua J., Bellin, Melena D., Kibbey, Richard G., Liesa, Marc, Shirihai, Orian S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971491/
https://ncbi.nlm.nih.gov/pubmed/31740442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0379
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