Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels

Fasting hyperinsulinemia precedes the development of type 2 diabetes. However, it is unclear whether fasting insulin hypersecretion is a primary driver of insulin resistance or a consequence of the progressive increase in fasting glycemia induced by insulin resistance in the prediabetic state. Herei...

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Vydáno v:Diabetes
Hlavní autoři: Taddeo, Evan P., Alsabeeh, Nour, Baghdasarian, Siyouneh, Wikstrom, Jakob D., Ritou, Eleni, Sereda, Samuel, Erion, Karel, Li, Jin, Stiles, Linsey, Abdulla, Muhamad, Swanson, Zachary, Wilhelm, Joshua J., Bellin, Melena D., Kibbey, Richard G., Liesa, Marc, Shirihai, Orian S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2020
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971491/
https://ncbi.nlm.nih.gov/pubmed/31740442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0379
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