Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation

Activation of platelet glycoprotein IIb-IIIa (GPIIb-IIIa; integrin αIIbβ3) leads to high-affinity fibrinogen binding and platelet aggregation during hemostasis. Whereas GTP-bound Rap1 GTPase promotes talin 1 binding to the β3 cytoplasmic domain to activate platelet GPIIb-IIIa, the Rap1 effector that...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood Adv
Egile Nagusiak: Lagarrigue, Frederic, Gingras, Alexandre R., Paul, David S., Valadez, Andrew J., Cuevas, Monica N., Sun, Hao, Lopez-Ramirez, Miguel A., Goult, Benjamin T., Shattil, Sanford J., Bergmeier, Wolfgang, Ginsberg, Mark H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2018
Gaiak:
Platelets and Thrombopoiesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156890/
https://ncbi.nlm.nih.gov/pubmed/30242097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018020487
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