The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium

The dynamic change from a globular conformation to an elongated fiber determines the ability of von Willebrand factor (VWF) to trap platelets. Fiber formation is favored by the anchorage of VWF to the endothelial cell surface, and VWF-platelet aggregates on the endothelium contribute to inflammation...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Kalagara, Thejaswi, Moutsis, Tracy, Yang, Yi, Pappelbaum, Karin I., Farken, Anne, Cladder-Micus, Lucia, Vidal-y-Sy, Sabine, John, Axel, Bauer, Alexander T., Moerschbacher, Bruno M., Schneider, Stefan W., Gorzelanny, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156889/
https://ncbi.nlm.nih.gov/pubmed/30237293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017013995
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