Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium

We previously demonstrated that the first intron of the human von Willebrand factor (vWF) is required for gene expression in the endothelium of transgenic mice. Based on this finding, we hypothesized that RNA splicing plays a role in mediating vWF expression in the vasculature. To address this quest...

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Detalhes bibliográficos
Main Authors: Yuan, Lei, Janes, Lauren, Beeler, David, Spokes, Katherine C., Smith, Joshua, Li, Dan, Jaminet, Shou-Ching, Oettgen, Peter, Aird, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663433/
https://ncbi.nlm.nih.gov/pubmed/23529929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-473785
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