Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory

PURPOSE: Physiologically-based pharmacokinetic (PBPK) models are essential in drug development, but require parameters that are not always obtainable. We developed a methodology to investigate the feasibility and requirements for precise and accurate estimation of PBPK parameters using population mo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Pharm Res
Main Authors: Calvier, Elisa A. M., Nguyen, Thu Thuy, Johnson, Trevor N., Rostami-Hodjegan, Amin, Tibboel, Dick, Krekels, Elke H. J., Knibbe, Catherijne A. J.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156772/
https://ncbi.nlm.nih.gov/pubmed/30218393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2487-1
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