Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast

The yeast genome becomes unstable during stress, which often results in adaptive aneuploidy, allowing rapid activation of protective mechanisms that restore cellular homeostasis. In this study, we performed a genetic screen in Saccharomyces cerevisiae to identify genome adaptations that confer resis...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Beaupere, Carine, Dinatto, Leticia, Wasko, Brian M., Chen, Rosalyn B., VanValkenburg, Lauren, Kiflezghi, Michael G., Lee, Mitchell B., Promislow, Daniel E. L., Dang, Weiwei, Kaeberlein, Matt, Labunskyy, Vyacheslav M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156608/
https://ncbi.nlm.nih.gov/pubmed/30185560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804264115
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