Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

Catching primal functional changes in early, ‘very far from disease onset’ (VFDO) stages of Huntington’s disease is likely to be the key to a successful therapy. Focusing on VFDO stages, we assessed neuronal microcircuits in premanifest Hdh150 knock-in mice. Employing in vivo two-photon Ca(2+) imagi...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Arnoux, Isabelle, Willam, Michael, Griesche, Nadine, Krummeich, Jennifer, Watari, Hirofumi, Offermann, Nina, Weber, Stephanie, Narayan Dey, Partha, Chen, Changwei, Monteiro, Olivia, Buettner, Sven, Meyer, Katharina, Bano, Daniele, Radyushkin, Konstantin, Langston, Rosamund, Lambert, Jeremy J, Wanker, Erich, Methner, Axel, Krauss, Sybille, Schweiger, Susann, Stroh, Albrecht
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2018
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156080/
https://ncbi.nlm.nih.gov/pubmed/30179155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38744
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