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Proscillaridin A exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastoma

Glioblastoma (GBM) is characterized by highly aggressive growth and invasive behavior. Due to the highly lethal nature of GBM, new therapies are urgently needed and repositioning of existing drugs is a promising approach. We have previously shown the activity of Proscillaridin A (ProA), a cardiac gl...

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Vydáno v:Cell Death Dis
Hlavní autoři: Berges, Raphael, Denicolai, Emilie, Tchoghandjian, Aurélie, Baeza-Kallee, Nathalie, Honore, Stephane, Figarella-Branger, Dominique, Braguer, Diane
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155148/
https://ncbi.nlm.nih.gov/pubmed/30250248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1018-7
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