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Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2
Activation of the nuclear factor erythroid 2–related factor 2 (Nrf2) antioxidant response signaling pathway is a major mechanism for the cellular defense against oxidative stress. Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependen...
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| Pubblicato in: | Chem Res Toxicol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6154506/ https://ncbi.nlm.nih.gov/pubmed/29658272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00062 |
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