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Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair

Human exposure to arsenic in drinking water is known to be associated with the development of bladder, lung, kidney, and skin cancers. The molecular mechanisms underlying the carcinogenic effects of arsenic species remain incompletely understood. DNA interstrand cross-links (ICLs) are among the most...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Jiang, Ji, Bellani, Marina, Li, Lin, Wang, Pengcheng, Seidman, Michael M., Wang, Yinsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586398/
https://ncbi.nlm.nih.gov/pubmed/28535027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01135
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