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Single Molecule Analysis of Laser Localized Interstrand Crosslinks

DNA interstrand crosslinks (ICLs) block unwinding of the double helix, and have always been regarded as major challenges to replication and transcription. Compounds that form these lesions are very toxic and are frequently used in cancer chemotherapy. We have developed two strategies, both based on...

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Bibliografski detalji
Izdano u:Front Genet
Glavni autori: Huang, Jing, Gali, Himabindu, Paramasivam, Manikandan, Muniandy, Parameswary, Gichimu, Julia, Bellani, Marina A., Seidman, Michael M.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860505/
https://ncbi.nlm.nih.gov/pubmed/27242893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00084
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