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Single Molecule Analysis of Laser Localized Interstrand Crosslinks

DNA interstrand crosslinks (ICLs) block unwinding of the double helix, and have always been regarded as major challenges to replication and transcription. Compounds that form these lesions are very toxic and are frequently used in cancer chemotherapy. We have developed two strategies, both based on...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Huang, Jing, Gali, Himabindu, Paramasivam, Manikandan, Muniandy, Parameswary, Gichimu, Julia, Bellani, Marina A., Seidman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860505/
https://ncbi.nlm.nih.gov/pubmed/27242893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00084
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