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Single Molecule Analysis of Laser Localized Interstrand Crosslinks

DNA interstrand crosslinks (ICLs) block unwinding of the double helix, and have always been regarded as major challenges to replication and transcription. Compounds that form these lesions are very toxic and are frequently used in cancer chemotherapy. We have developed two strategies, both based on...

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Bibliografske podrobnosti
izdano v:Front Genet
Main Authors: Huang, Jing, Gali, Himabindu, Paramasivam, Manikandan, Muniandy, Parameswary, Gichimu, Julia, Bellani, Marina A., Seidman, Michael M.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860505/
https://ncbi.nlm.nih.gov/pubmed/27242893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00084
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