Repair of Laser-localized DNA Interstrand Cross-links in G(1) Phase Mammalian Cells

Interstrand cross-links (ICLs) are absolute blocks to transcription and replication and can provoke genomic instability and cell death. Studies in bacteria define a two-stage repair scheme, the first involving recognition and incision on either side of the cross-link on one strand (unhooking), follo...

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Main Authors: Muniandy, Parameswary A., Thapa, Dennis, Thazhathveetil, Arun Kalliat, Liu, Su-ting, Seidman, Michael M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788842/
https://ncbi.nlm.nih.gov/pubmed/19684342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029025
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