Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2

Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins. Although the CDC45 MCM GINS (CMG) structure implies that interstrand crosslinks (ICLs) are absolu...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Huang, Jing, Zhang, Jing, Bellani, Marina A., Pokharel, Durga, Gichimu, Julia, James, Ryan C., Gali, Himabindu, Ling, Chen, Yan, Zhijiang, Xu, Dongyi, Chen, Junjie, Meetei, Amom Ruhikanta, Li, Lei, Wang, Weidong, Seidman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676478/
https://ncbi.nlm.nih.gov/pubmed/31067464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.04.032
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