Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2

Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins. Although the CDC45 MCM GINS (CMG) structure implies that interstrand crosslinks (ICLs) are absolu...

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Publicat a:Cell Rep
Autors principals: Huang, Jing, Zhang, Jing, Bellani, Marina A., Pokharel, Durga, Gichimu, Julia, James, Ryan C., Gali, Himabindu, Ling, Chen, Yan, Zhijiang, Xu, Dongyi, Chen, Junjie, Meetei, Amom Ruhikanta, Li, Lei, Wang, Weidong, Seidman, Michael M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676478/
https://ncbi.nlm.nih.gov/pubmed/31067464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.04.032
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