Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-Strand Break Repair

[Image: see text] Arsenic is a widespread environmental contaminant. However, the exact molecular mechanisms underlying the carcinogenic effects of arsenic remain incompletely understood. Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-RNF40 heterodimer...

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Bibliographic Details
Main Authors: Zhang, Fan, Paramasivam, Manikandan, Cai, Qian, Dai, Xiaoxia, Wang, Pengcheng, Lin, Krystal, Song, Jikui, Seidman, Michael M., Wang, Yinsheng
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183597/
https://ncbi.nlm.nih.gov/pubmed/25170678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507863d
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