Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-Strand Break Repair

[Image: see text] Arsenic is a widespread environmental contaminant. However, the exact molecular mechanisms underlying the carcinogenic effects of arsenic remain incompletely understood. Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-RNF40 heterodimer...

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Päätekijät: Zhang, Fan, Paramasivam, Manikandan, Cai, Qian, Dai, Xiaoxia, Wang, Pengcheng, Lin, Krystal, Song, Jikui, Seidman, Michael M., Wang, Yinsheng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183597/
https://ncbi.nlm.nih.gov/pubmed/25170678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507863d
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