Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

Maintaining genomic integrity is critical to avoid life-threatening disorders, such as premature aging, neurodegeneration and cancer. A multiprotein cascade operates at sites of DNA double-strand breaks (DSBs) to recognize, signal and repair damage. RNF168 (ring-finger nuclear factor) contributes to...

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Main Authors: Devgan, S S, Sanal, O, Doil, C, Nakamura, K, Nahas, S A, Pettijohn, K, Bartek, J, Lukas, C, Lukas, J, Gatti, R A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178430/
https://ncbi.nlm.nih.gov/pubmed/21394101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.18
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