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Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle

The assembly of hepatitis B virus (HBV) core protein (HBc) into capsids represents a critical step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it an attractive target for antiviral therapies. Capsid assembly modulators (CAMs) induce the formation of empty...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Lahlali, Thomas, Berke, Jan Martin, Vergauwen, Karen, Foca, Adrien, Vandyck, Koen, Pauwels, Frederik, Zoulim, Fabien, Durantel, David
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153789/
https://ncbi.nlm.nih.gov/pubmed/30012770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00835-18
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